Journal: Bone

Article Title: Focal osteoporosis defects play a key role in hip fracture

doi: 10.1016/j.bone.2016.10.020

Figure Lengend Snippet: . Bone Mapping (CBM) ROIs. Statistically significant differences in cortical (a) and trabecular (b) bone between hip fracture ( n = 70, 50 female, 20 male) and 70 healthy controls shown as a colour map on the canonical femur model. CMSD Cortical Mass Surface Density, ECTD Endocortical Trabecular Density . Cortical (c) and trabecular (d) differences between female femoral neck patients ( n = 86) and controls ( n = 125). Cortical (e) and trabecular (f) differences between female trochanteric fracture patients ( n = 52) and controls ( n = 125). The black arrow highlights the biopsy site for . . Cortical (g) differences between frail female patients with at least one injurious fall ( n = 50) versus 50 healthy controls (no difference in trabecular bone (h) ).

Article Snippet: In the FEMCO case-control clinical study, Cortical Bone Mapping (CBM) was applied to clinical computed tomography (CT) scans to define 3D cortical and trabecular bone defects in patients with acute hip fracture compared to controls.

Techniques:

Journal: Bone

Article Title: Focal osteoporosis defects play a key role in hip fracture

doi: 10.1016/j.bone.2016.10.020

Figure Lengend Snippet: a ) Area Under the Curve (AUC) from Receiver Operating Characteristic analysis for the ability of age, height, Femoral neck (Fn) and Total Hip (Th) DXA-like areal Bone Mineral Density (aBMD) from CT to correctly categorise hip fracture types (grey lines- dotted for TR or dashed for FN) as well as all hip fractures (black solid lines-ALL HIP FX). ROC analysis for different combinations of the novel 3D Cortical Bone Mapping (CBM) measures to correctly discriminate hip fractures (5b–d). An average single measure of 3D Cortical Mass Surface Density or Trabecular Density (ECTD) was taken for each patient from the bone mapping ROIs (shown as patches in c–f). The ability of age, height and an average 3D measure of either CMSD ( 5b ), ECTD ( 5c ) or both CMSD and ECTD ( 5d ) to correctly discriminate fractures, as well as the corresponding AUC values and 95% confidence intervals for discriminating all fractures (ALL FX), Trochanteric fractures (TR) and Femoral neck (FN) are shown.

Article Snippet: In the FEMCO case-control clinical study, Cortical Bone Mapping (CBM) was applied to clinical computed tomography (CT) scans to define 3D cortical and trabecular bone defects in patients with acute hip fracture compared to controls.

Techniques: